Psychedelics as Non-Specific Amplifiers
Cultural Feedback Loops and Implications for Psychedelic Science. A Commentary on Return to the Real by Ten Berge
DOI:
https://doi.org/10.31156/jaex.27866Keywords:
Psychedelics, Cultural Feedback Loops, Set and setting, Chemiosocialities, Mystical experiences;, Reflexivity, Discourse analysis, Psychedelic neuroscienceAbstract
Return to the Real describes how culturally prevalent narratives shape psychedelic experience. Building on Ten Berge’s two-part analysis, our commentary argues that psychedelic effects are best understood within cultural feedback loops linking cultural set and setting, individual expectations, experience, and its articulation back into culture. On this view, psychedelics operate primarily as non-specific amplifiers and catalysts that magnify pre-existing beliefs, rather than revealing unmediated insights. We situate this thesis in relation to contemporary neuroscientific models of the psychedelic experience (CSTC, REBUS), humanistic and anthropological accounts, and evidence on socio-political belief change and clinical outcomes. We show how the apparent “disruptive” effects of psychedelics can often be reinterpreted as context-dependent intensifications. We then identify methodological and ideological obstacles to studying culture in psychedelic science and propose a mixed-methods program, including reflexivity, discourse analytics, neurophenomenology, and naturalistic cohort comparisons, to operationalize cultural variables. Recognizing culture’s constitutive role has ethical and epistemic consequences including caution with respect to metaphysical claims and attention to how psychedelics induce change in clinical settings. By bridging the humanities and cognitive neuroscience we can build a cumulative, culture-sensitive science of psychedelics.
References
Barad, K. (2007). Meeting the universe halfway: Quantum physics and the entanglement of matter and meaning. Duke university Press.
Bourdieu, P. (1977). Outline of a theory of practice (R. Nice, Trans.). Cambridge University Press.
Cardeña, E., & Pekala, R. J. (2014). Researching states of consciousness and anomalous experiences. In E. Cardeña, S. J. Lynn, & S. Krippner (Eds.), Varieties of anomalous experience: Examining the scientific evidence (2nd ed., pp. 21–56). American Psychological Association. https://doi.org/10.1037/14258-002
Chamberlain, K., McGuigan, K., Anstiss, D., & Marshall, K. (2018). A change of view: arts-based research and psychology. Qualitative Research in Psychology, 15(2–3), 131–139. https://doi.org/10.1080/14780887.2018.1456590
Devenot, N. (2023). TESCREAL hallucinations: Psychedelic and AI hype as inequality engines. Journal of Psychedelic Studies, 7(S1), 22-39. https://doi.org/10.1556/2054.2023.00292
Dupuis, D. (2022). The socialization of hallucinations: Cultural priors, social interactions, and contextual factors in the use of psychedelics. Transcultural Psychiatry, 59(5), 625-637. https://doi.org/10.1177/1363461521103638
Erritzoe, D., Roseman, L., Nour, M. M., MacLean, K., Kaelen, M., Nutt, D. J., & Carhart‐Harris, R. (2018). Effects of psilocybin therapy on personality structure. Acta Psychiatrica Scandinavica, 138(5), 368-378. https://doi.org/10.1111/acps.12904
Fiesler, C., & Proferes, N. (2018). “Participant” perceptions of Twitter research ethics. Social Media+ Society, 4(1), 2056305118763366. https://doi.org/10.1177/205630511876336
Forstmann, M., & Sagioglou, C. (2017). Lifetime experience with (classic) psychedelics predicts pro-environmental behavior through an increase in nature relatedness. Journal of Psychopharmacology, 31(8), 975-988. https://doi.org/10.1177/0269881117714049
Gao, C. X., Dwyer, D., Zhu, Y., Smith, C. L., Du, L., Filia, K. M., ... & Cotton, S. M. (2023). An overview of clustering methods with guidelines for application in mental health research. Psychiatry Research, 327, 115265. https://doi.org/10.1016/j.psychres.2023.115265
Gearin, A. K., & Devenot, N. (2021). Psychedelic medicalization, public discourse, and the morality of ego dissolution. International Journal of Cultural Studies, 24(6), 917-935. https://doi.org/10.1177/13678779211019424
Gier N (2014) The origins of religious violence: An Asian perspective. Lexington Books.
Graziosi, M., Singh, M., Nayak, S. M., & Yaden, D. B. (2023). Acute subjective effects of psychedelics within and beyond WEIRD contexts. Journal of Psychoactive Drugs, 55(5), 558-569. https://doi.org/10.1080/02791072.2023.2255274
Gupta, A. (2023). BERT for discourse analysis: A pragmatist approach to governmentality (Doctoral dissertation, University of Bristol).
Hall, E.T. (1973). The silent language. Anchor Books.
Hartogsohn, I. (2017). Constructing drug effects: A history of set and setting. Drug Science, Policy and Law, 3, 2050324516683325. https://doi.org/10.1177/2050324516683325
Hauskeller, C. (2022). Individualization and Alienation in Psychedelic Psychotherapy. In C. Hauskeller & P. Sjöstedt-Hughes (Eds.), Philosophy and psychedelics: Frameworks for exceptional experience. Bloomsbury Publishing.
Henrich, J., Heine, S. J., & Norenzayan, A. (2010). Beyond WEIRD: Towards a broad-based behavioral science. Behavioral and Brain Sciences, 33(2-3), 111. https://doi.org/10.1017/S0140525X10000725
Holm, S., Petersen, M. A., Enghoff, O., & Hesse, M. (2023). Psychedelic discourses: A qualitative study of discussions in a Danish online forum. International Journal of Drug Policy, 112, 103945. https://doi.org/10.1016/j.drugpo.2022.103945
Jamieson, M. K., Govaart, G. H., & Pownall, M. (2023). Reflexivity in quantitative research: A rationale and beginner's guide. Social and Personality Psychology Compass, 17(4), e12735. https://doi.org/10.1111/spc3.12735
Kangaslampi, S. (2023). Association between mystical-type experiences under psychedelics and improvements in well-being or mental health–A comprehensive review of the evidence. Journal of Psychedelic Studies, 7(1), 18-28. https://doi.org/10.1556/2054.2023.00243
Kałużna, A., Schlosser, M., Gulliksen Craste, E., Stroud, J., & Cooke, J. (2022). Being no one, being One: The role of ego-dissolution and connectedness in the therapeutic effects of psychedelic experience. Journal of Psychedelic Studies. https://doi.org/10.1556/2054.2022.00199
Karhulahti V. M. (2024). Positionality statements in science. Open research Europe, 4, 62. https://doi.org/10.12688/openreseurope.17058.2
Langlitz, N., Dyck, E., Scheidegger, M., & Repantis, D. (2021). Moral psychopharmacology needs moral inquiry: The case of psychedelics. Frontiers in Psychiatry, 12, 680064. https://doi.org/10.3389/fpsyt.2021.680064
Lyon, A. (2023). Psychedelic experience. Oxford University Press.
Margolin, I., Pearson, T., & Jones, A. (2024). Arts-based research in psychology: A means to unearth creative wisdom. Methods in Psychology, 11, 100144. https://doi.org/10.1016/j.metip.2024.100144
Noorani, T., Bedi, G., & Muthukumaraswamy, S. (2023). Dark loops: Contagion effects, consistency and chemosocial matrices in psychedelic-assisted therapy trials. Psychological Medicine, 53(13), 5892-5901. doi:10.1017/S0033291723001289
Nour, M. M., Evans, L., Nutt, D., & Carhart-Harris, R. L. (2016). Ego-dissolution and psychedelics: Validation of the ego-dissolution inventory (EDI). Frontiers in Human Neuroscience, 10, 190474. https://doi.org/10.3389/fnhum.2016.00269
Oram, M. (2018). The trials of psychedelic therapy: LSD psychotherapy in America. JHU Press.
Oswald, F. (2024). Positionality statements should not force us to ‘out’ourselves. Nature Human Behaviour, 8(2), 185-185. https://doi.org/10.1038/s41562-023-01812-5
Pace, B. A., & Devenot, N. (2021). Right-wing psychedelia: Case studies in cultural plasticity and political pluripotency. Frontiers in Psychology, 12, 733185. https://doi.org/10.3389/fpsyg.2021.733185
Sadowska, Z., (2023, April 20-22). Força (power) and ayahuasca multiplicity. [Conference presentation]. Breaking Convention 2023, Exeter, United Kingdom. https://www.youtube.com/watch?v=uMeeCbQYlk4
Safron, A., Juliani, A., Reggente, N., Klimaj, V., & Johnson, M. (2025). On the varieties of conscious experiences: Altered beliefs under psychedelics (ALBUS). Neuroscience of Consciousness, 2025(1), niae038. https://doi.org/10.1093/nc/niae038
Sanchez Petrement, M. (2023). Historicizing psychedelics: counterculture, renaissance, and the neoliberal matrix. Frontiers in Sociology, 8, 1114523. https://doi.org/10.3389/fsoc.2023.1114523
Savolainen, J., Casey, P. J., McBrayer, J. P., & Schwerdtle, P. N. (2023). Positionality and its problems: Questioning the value of reflexivity statements in research. Perspectives on Psychological Science, 18(6), 1331-1338. https://doi.org/10.1177/17456916221144988
Sopanen, J. (2022). Journeying in the realm of unconsciousness: Carl Jung’s Liber Novus and psychedelic experience. In C. Hauskeller & P. Sjöstedt-Hughes (Eds.), Philosophy and psychedelics: Frameworks for exceptional experience. Bloomsbury Publishing.
Timmermann, C., Kettner, H., Letheby, C., Roseman, L., Rosas, F. E., & Carhart-Harris, R. L. (2021). Psychedelics alter metaphysical beliefs. Scientific reports, 11(1), 22166. https://doi.org/10.1038/s41598-021-01209-2
Townsend, L., & Wallace, C. (2016). Social media research: A guide to ethics. The University of Aberdeen.
van Elk, M., & Fried, E. I. (2023). History repeating: Guidelines to address common problems in psychedelic science. Therapeutic Advances in Psychopharmacology, 13, 20451253231198466. https://doi.org/10.1177/20451253231198466
van Elk, M., & Yaden, D. B. (2022). Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review. Neuroscience & Biobehavioral Reviews, 140, 104793. https://doi.org/10.1016/j.neubiorev.2022.104793
Van Leeuwen, N., & van Elk, M. (2019). Seeking the supernatural: The interactive religious experience model. Religion, Brain & Behavior, 9(3), 221-251.
https://doi.org/10.1080/2153599X.2018.1453529
Victoria, B. D. (2022). Was D. T. Suzuki a Nazi sympathizer? In J. Breen, S. Fumihiko, & Y. Shōji (Eds.), Beyond Zen: D. T. Suzuki and the modern transformation of Buddhism (pp. 84–107). University of Hawai’i Press. https://doi.org/10.2307/j.ctv270ktxr
Vollenweider, F. X., & Preller, K. H. (2020). Psychedelic drugs: Neurobiology and potential for treatment of psychiatric disorders. Nature Reviews Neuroscience, 21(11), 611-624. https://doi.org/10.1038/s41583-020-0367-2)
Weiss, B., Sleep, C. E., Beller, N. M., Erritzoe, D., & Campbell, W. K. (2023). Perceptions of psychedelic personality change, determinants of use, setting and drug moderation: Toward a holistic model. Journal of Psychedelic Studies, 7(3), 200-226. https://doi.org/10.1556/2054.2023.00291
Xu, W. W., Tshimula, J. M., Dubé, È., Graham, J. E., Greyson, D., MacDonald, N. E., & Meyer, S. B. (2022). Unmasking the Twitter discourses on masks during the COVID-19 pandemic: User cluster–based BERT topic modeling approach. Jmir Infodemiology, 2(2), e41198. doi:10.2196/41198
Zembylas, M. (2025). Rethinking positionality statements in research: from looking back to building solidarity. International Journal of Research & Method in Education, 1-13. https://doi.org/10.1080/1743727X.2025.2475762
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Anastasia Ruban, Michiel van Elk

This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles published in JAEX are open access, freely and universally accessible online, and archived in the open journal’s Lund University website (https://journals.lub.lu.se). Articles in JAEX can be distributed under the terms of the Creative Commons Attribution 4.0 International License CCBY (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, with appropriate credit to the original author(s) and the source, a link to the Creative Commons license, and an indication if changes were made.
